The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
Identifieur interne : 009964 ( Main/Exploration ); précédent : 009963; suivant : 009965The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
Auteurs : Tsutomu Kume ; Haiyan Jiang ; Jolanta M. Topczewska ; Brigid L. M. HoganSource :
- Genes & Development [ 0890-9369 ] ; 2001.
Abstract
The murine
Url:
DOI: 10.1101/gad.907301
PubMed: 11562355
PubMed Central: 312788
Affiliations:
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<author><name sortKey="Jiang, Haiyan" sort="Jiang, Haiyan" uniqKey="Jiang H" first="Haiyan" last="Jiang">Haiyan Jiang</name>
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<author><name sortKey="Topczewska, Jolanta M" sort="Topczewska, Jolanta M" uniqKey="Topczewska J" first="Jolanta M." last="Topczewska">Jolanta M. Topczewska</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis</title>
<author><name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name>
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<author><name sortKey="Jiang, Haiyan" sort="Jiang, Haiyan" uniqKey="Jiang H" first="Haiyan" last="Jiang">Haiyan Jiang</name>
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<author><name sortKey="Topczewska, Jolanta M" sort="Topczewska, Jolanta M" uniqKey="Topczewska J" first="Jolanta M." last="Topczewska">Jolanta M. Topczewska</name>
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<author><name sortKey="Hogan, Brigid L M" sort="Hogan, Brigid L M" uniqKey="Hogan B" first="Brigid L. M." last="Hogan">Brigid L. M. Hogan</name>
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<series><title level="j">Genes & Development</title>
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<imprint><date when="2001">2001</date>
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<front><div type="abstract" xml:lang="en"><p>The murine <italic>Foxc1/Mf1</italic>
and <italic>Foxc2/Mfh1</italic>
genes encode closely related forkhead/winged helix transcription factors with overlapping expression in the forming somites and head mesoderm and endothelial and mesenchymal cells of the developing heart and blood vessels. Embryos lacking either <italic>Foxc1</italic>
or <italic>Foxc2</italic>
, and most compound heterozygotes, die pre- or perinatally with similar abnormal phenotypes, including defects in the axial skeleton and cardiovascular system. However, somites and major blood vessels do form. This suggested that the genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels, and somites. In support of this hypothesis, we show here that compound <italic>Foxc1</italic>
; <italic>Foxc2</italic>
homozygotes die earlier and with much more severe defects than single homozygotes alone. Significantly, they have profound abnormalities in the first and second branchial arches, and the early remodeling of blood vessels. Moreover, they show a complete absence of segmented paraxial mesoderm, including anterior somites. Analysis of compound homozygotes shows that <italic>Foxc1</italic>
and <italic>Foxc2</italic>
are both required for transcription in the anterior presomitic mesoderm of <italic>paraxis</italic>
, <italic>Mesp1</italic>
, <italic>Mesp2</italic>
, <italic>Hes5</italic>
, and <italic>Notch1</italic>
, and for the formation of sharp boundaries of <italic>Dll1</italic>
, <italic>Lfng</italic>
, and <italic>ephrinB2</italic>
expression. We propose that the two genes interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop.</p>
</div>
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<tree><noCountry><name sortKey="Hogan, Brigid L M" sort="Hogan, Brigid L M" uniqKey="Hogan B" first="Brigid L. M." last="Hogan">Brigid L. M. Hogan</name>
<name sortKey="Jiang, Haiyan" sort="Jiang, Haiyan" uniqKey="Jiang H" first="Haiyan" last="Jiang">Haiyan Jiang</name>
<name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name>
<name sortKey="Topczewska, Jolanta M" sort="Topczewska, Jolanta M" uniqKey="Topczewska J" first="Jolanta M." last="Topczewska">Jolanta M. Topczewska</name>
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